Publication bias is a substantial problem for the credibility of research in general and of meta-
analyses in particular, as it yields overestimated effects and may suggest the existence of …

To our knowledge, no previous meta-analysis has attempted to compare the efficacy of
pharmacological, psychological and combined treatments for the three main anxiety …

Aim This is the third version of the guideline of the World Federation of Societies of
Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety …

Background Clinical research affecting how doctors practice medicine is increasingly
sponsored by companies that make drugs and medical devices. Previous systematic …

The clinical trial is “the most definitive tool for evaluation of the applicability of clinical
research.” It represents “a key research activity with the potential to improve the quality of …

Objectives: To determine which multicenter randomized controlled trials in critically ill
patients have shown that the study intervention was associated with a statistically significant …

Introduction Lung cancer is the leading cause of years of life lost because of cancer and is
associated with the highest economic burden relative to other tumor types. Research …

Objectives To analyse developments (and their causes) in the number and proportion of
clinical trials that were registered in different parts of the world after the International …

Background The synthesis of published research in systematic reviews is essential when
providing evidence to inform clinical and health policy decision-making. However, the …

Publication bias is a well‐known threat to the validity of meta‐analyses and, more broadly,
the reproducibility of scientific findings. When policies and recommendations are predicated …