Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Astrocytes in physiological aging and Alzheimer's disease

JJ Rodríguez-Arellano, V Parpura, R Zorec… - Neuroscience, 2016 - Elsevier
Astrocytes are fundamental for homoeostasis, defence and regeneration of the central
nervous system. Loss of astroglial function and astroglial reactivity contributes to the aging of …

Glial cells in (patho) physiology

V Parpura, MT Heneka, V Montana… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 121, 4–27. Abstract Neuroglial cells define brain homeostasis and
mount defense against pathological insults. Astroglia regulate neurogenesis and …

Astrocytes and major depression: The purinergic avenue

YF Zhao, A Verkhratsky, Y Tang, P Illes - Neuropharmacology, 2022 - Elsevier
Major depressive disorder (MDD) is one of the most prevalent psychiatric illnesses
worldwide which impairs the social functioning of the afflicted patients. Astrocytes promote …

The tripartite glutamatergic synapse

U Lalo, W Koh, CJ Lee, Y Pankratov - Neuropharmacology, 2021 - Elsevier
Astroglial cells were long considered as structural and metabolic supporting cells are which
do not directly participate in information processing in the brain. Discoveries of …

Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity

A Popov, A Brazhe, P Denisov, O Sutyagina, L Li… - Aging cell, 2021 - Wiley Online Library
Little is known about age‐dependent changes in structure and function of astrocytes and of
the impact of these on the cognitive decline in the senescent brain. The prevalent view on …

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex

U Lalo, O Palygin, S Rasooli-Nejad, J Andrew… - PLoS …, 2014 - journals.plos.org
Communication between neuronal and glial cells is important for many brain functions.
Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various …

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

A Verkhratsky, M Augusto-Oliveira, A Pivoriūnas… - … -European Journal of …, 2021 - Springer
Astroglia represent a class of heterogeneous, in form and function, cells known as
astrocytes, which provide for homoeostasis and defence of the central nervous system …

[HTML][HTML] Glia: victims or villains of the aging brain?

IH Salas, J Burgado, NJ Allen - Neurobiology of Disease, 2020 - Elsevier
Aging is the strongest risk factor for metabolic, vascular and neurodegenerative diseases.
Aging alone is associated with a gradual decline of cognitive and motor functions …