Melanoma is a potentially fatal skin malignancy that continues to increase in incidence
worldwide. The current lifetime risk of developing melanoma is 1 in 63 in the United States …

Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …

Retinoblastoma is an aggressive eye cancer of infancy and childhood. Survival and the
chance of saving vision depend on severity of disease at presentation. Retinoblastoma was …

Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

The management of retinoblastoma, the most common intraocular malignancy in children,
has changed drastically over the last decade. Landmark developments in local drug …

The Childhood Cancer Survivor Study (CCSS) has assembled the largest cohort to date for
assessment of late mortality. Vital status and cause of death of all patients eligible for …

Retinoblastoma (RB) is the most common intraocular malignancy in childhood.
Approximately 40% of retinoblastomas are hereditary and due to germline mutations in the …

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to
preserve life, with ocular survival, visual preservation and quality of life as secondary aims …

Melanoma is a cancer arising from the malignant transformation of melanocytes. These
pigment-producing cells derive embryologically from pluripotent neural crest stem cells …

Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …