An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral
circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal …

The multifaceted nature of the renin-angiotensin system (RAS) makes it versatile due to its
involvement in pathogenesis of the cardiovascular disease. Angiotensin II (Ang II), a …

Abstract The Na+-Cl− cotransporter (NCC) drives salt reabsorption in the kidney and plays a
decisive role in balancing electrolytes and blood pressure. Thiazide and thiazide-like …

Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members,
WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in …

Stroke is one of the major culprits responsible for morbidity and mortality worldwide, and the
currently available pharmacological strategies to combat this global disease are scanty …

SPAK inhibitor ZT-1a was previously shown to be neuroprotective in murine ischemic stroke
models. In this study, we further examined the efficacy of four ZT-1a derivatives (ZT-1c,-1d …

The kidney regulates blood pressure through salt/water reabsorption affected by tubular
sodium transporters. Expanding our prior research on placental cluster of differentiation 81 …

Background Hyperoxia downregulates the tight junction (TJ) proteins of the alveolar
epithelium and leads to barrier dysfunction. Previous study has showed that STE20/SPS1 …

Kinase inhibitors are a significant and continuously developing division of target
therapeutics. The drug discovery and improvement efforts have examined numerous …

Approximately 14% of the general population suffer from chronic kidney disease that can
lead to acute kidney injury (AKI), a condition with up to 50% mortality for which there is no …