A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies
The intricate molecular pathways governing cancer development and progression have
spurred intensive investigations into novel therapeutic targets. Glycogen Synthase Kinase-3 …
spurred intensive investigations into novel therapeutic targets. Glycogen Synthase Kinase-3 …
GSK3β: role in therapeutic landscape and development of modulators
S Phukan, VS Babu, A Kannoji… - British journal of …, 2010 - Wiley Online Library
Glycogen synthase kinase‐3 beta (GSK3β) is a multifunctional serine/threonine kinase
which was originally identified as a regulator of glycogen metabolism. It plays a key role in …
which was originally identified as a regulator of glycogen metabolism. It plays a key role in …
QSAR studies in the discovery of novel type-II diabetic therapies
A Abuhammad, MO Taha - Expert opinion on drug discovery, 2016 - Taylor & Francis
Introduction: Type-II diabetes mellitus (T2DM) is a complex chronic disease that represents a
major therapeutic challenge. Despite extensive efforts in T2DM drug development, therapies …
major therapeutic challenge. Despite extensive efforts in T2DM drug development, therapies …
[HTML][HTML] Synthesis, computational studies and anticonvulsant activity of novel benzothiazole coupled sulfonamide derivatives
We report herein the synthesis of ¾ substituted benzene sulfonamides linked via phenyl ring
to a benzothiazole moiety. The title compounds in the two series namely N-(4 …
to a benzothiazole moiety. The title compounds in the two series namely N-(4 …
Allosteric regulation of glycogen synthase kinase 3β: a theoretical study
Glycogen synthase kinase 3β (GSK-3β) is a serine− threonine kinase belonging to the
CMGC family that plays a key role in many biological processes, such as glucose …
CMGC family that plays a key role in many biological processes, such as glucose …
Monte Carlo method based QSAR modeling of maleimide derivatives as glycogen synthase kinase-3β inhibitors
JV Živković, NV Trutić, JB Veselinović… - Computers in biology …, 2015 - Elsevier
Abstract The Monte Carlo method was used for QSAR modeling of maleimide derivatives as
glycogen synthase kinase-3β inhibitors. The first QSAR model was developed for a series of …
glycogen synthase kinase-3β inhibitors. The first QSAR model was developed for a series of …
Role of bridging water molecules in GSK3β‐inhibitor complexes: Insights from QM/MM, MD, and molecular docking studies
SY Lu, YJ Jiang, J Lv, JW Zou… - Journal of Computational …, 2011 - Wiley Online Library
The role of water molecules is increasingly gaining interest in drug design, and several
studies have highlighted their paramount contributions to the specificity and the affinity of …
studies have highlighted their paramount contributions to the specificity and the affinity of …
Advances in quantitative structure–activity relationship models of anti-Alzheimer's agents
Introduction: Alzheimer's disease (AD) is one of the lethal diseases, mainly affecting older
people. The unclear root cause and involvement of various enzymes in the pathological …
people. The unclear root cause and involvement of various enzymes in the pathological …
A new protocol for predicting novel GSK-3β ATP competitive inhibitors
Glycogen synthase kinase 3β (GSK-3β) is a potential therapeutic target for cancer, type-2
diabetes, and Alzheimer's disease. This paper proposes a new lead identification protocol …
diabetes, and Alzheimer's disease. This paper proposes a new lead identification protocol …
Pharmacophore-based screening and drug repurposing exemplified on glycogen synthase kinase-3 inhibitors
The current study was conducted to elaborate a novel pharmacophore model to accurately
map selective glycogen synthase kinase-3 (GSK-3) inhibitors, and perform virtual screening …
map selective glycogen synthase kinase-3 (GSK-3) inhibitors, and perform virtual screening …