Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and
clinical studies but may be difficult to sustain. As an alternative to CR, there has been …

Cancer cells acquire distinct metabolic preferences based on their tissue of origin, genetic
alterations and degree of interaction with systemic hormones and metabolites. These …

Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

The vulnerability of cancer cells to nutrient deprivation and their dependency on specific
metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) …

Cancers are among the leading causes of morbidity and mortality worldwide, and the
number of new cases is expected to rise significantly over the next decades. At the same …

Most animals alternate periods of feeding with periods of fasting often coinciding with sleep.
Upon> 24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic …

Elevated circulating insulin levels are frequently observed in the setting of obesity and early
type 2 diabetes, as a result of insensitivity of metabolic tissues to the effects of insulin. Higher …

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …

Cancer is a leading cause of death worldwide, and its incidence is continually increasing.
Although anticancer therapy has improved significantly, it still has limited efficacy for tumor …