The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …

Neuronal circuits in the brain are shaped by experience during'critical periods' in early
postnatal life. In the primary visual cortex, this activity-dependent development is triggered …

N-methyl-d-aspartate receptors (NMDARs) are present at many excitatory glutamate
synapses in the central nervous system and display unique properties that depend on their …

Synaptic plasticity is a key component of the learning machinery in the brain. It is vital that
such plasticity be tightly regulated so that it occurs to the proper extent at the proper time …

The number and subunit composition of synaptic N-methyl-d-aspartate receptors (NMDARs)
are not static, but change in a cell-and synapse-specific manner during development and in …

Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul
Munro's' Theory for the development of neuron selectivity: orientation specificity and …

We report that variations in maternal care in the rat promote hippocampal synaptogenesis
and spatial learning and memory through systems known to mediate experience-dependent …

Infantile amnesia, the inability of adults to recollect early episodic memories, is associated
with the rapid forgetting that occurs in childhood. It has been suggested that infantile …