The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

The successful outcomes of chimeric antigen receptor (CAR) T-cell therapy in treating
hematologic cancers have increased the previously unprecedented excitement to use this …

Adoptive T cell therapy (ACT) refers to the therapeutic use of T cells. T cells genetically
engineered to express chimeric antigen receptors (CAR) constitute the most clinically …

Infusion of chimeric antigen receptor (CAR)-genetically modified T cells (CAR-T cells) have
led to remarkable clinical responses and cancer remission in patients suffering from …

Cancer immunotherapy has changed the treatment landscape for cancer patients, especially
for those with metastatic spread. While the immunotherapeutic armamentarium is constantly …

Integrins belong to a large family of αβ heterodimeric transmembrane proteins first
recognized as adhesion molecules that bind to dedicated elements of the extracellular …

Integrins are heterodimeric cell surface receptors composed of α and β subunits that control
adhesion, proliferation and gene expression. The integrin heterodimer binding to ligand …

Simple Summary Pancreatic cancer (PC) is a highly aggressive malignant tumor with an
extremely poor prognosis. Early diagnosis and treatment are key to improving the survival …

Human integrin receptors are important for cell-cell and cell-matrix adhesion in normal
epithelial cells. Emerging evidences have indicated integrin members are involved in cancer …

Chimeric antigen receptor (CAR)-T cell therapy has had unprecedented impact in the
treatment of hematological malignancies with few therapeutic options. However, it is clear …