Liposomes are nanocarriers comprised of lipid bilayers encapsulating an aqueous core. The
ability of liposomes to encapsulate a wide variety of diagnostic and therapeutic agents has …

Gene therapy is becoming an influential part of the rapidly increasing armamentarium of
biopharmaceuticals for improving health and combating diseases. Currently, three gene …

Following systemic administration, liposomes are covered by a 'corona'of proteins, and
preserving the surface functionality is challenging. Coating the liposome surface with …

Active targeting that exploits the (over) expression of surface receptors in target cells by
ligand incorporation is a central concept in nanomedicine research. Despite unprecedented …

When nanoparticles (NPs) enter a biological fluid (eg, human plasma (HP)), proteins and
other biomolecules adsorb on the surface leading to formation of a rich protein shell …

Although an established drug delivery platform, liposomes have not fulfilled their true
potential. In the body, interactions of liposomes are mediated by the layer of plasma proteins …

When injected in a biological milieu, a nanomaterial rapidly adsorbs biomolecules forming a
biomolecular corona. The biomolecular corona changes the interfacial composition of a …

Growing developments in engineered nanomaterials (NMs) and their wide applications
inevitably raise environmental and human health concerns. Upon contact with biological …

As soon as nanomaterials, such as nanoparticles (NPs), are injected into a physiological
environment a rich coating of biomolecules known as the “protein corona” rapidly covers …

The concept that the effective unit of interest in the cell–nanomaterial interaction is the
particle and its corona of associated proteins is emerging. Here we investigate the …