Prevention and treatment of acute lung injury with time-controlled adaptive ventilation: physiologically informed modification of airway pressure release ventilation
GF Nieman, LA Gatto, P Andrews, J Satalin… - Annals of intensive …, 2020 - Springer
Mortality in acute respiratory distress syndrome (ARDS) remains unacceptably high at
approximately 39%. One of the only treatments is supportive: mechanical ventilation …
approximately 39%. One of the only treatments is supportive: mechanical ventilation …
Myths and misconceptions of airway pressure release ventilation: getting past the noise and on to the signal
P Andrews, J Shiber, M Madden, GF Nieman… - Frontiers in …, 2022 - frontiersin.org
In the pursuit of science, competitive ideas and debate are necessary means to attain
knowledge and expose our ignorance. To quote Murray Gell-Mann (1969 Nobel Prize …
knowledge and expose our ignorance. To quote Murray Gell-Mann (1969 Nobel Prize …
Functional lung imaging with synchrotron radiation: Methods and preclinical applications
S Bayat, L Porra, P Suortti, W Thomlinson - Physica Medica, 2020 - Elsevier
Many lung disease processes are characterized by structural and functional heterogeneity
that is not directly appreciable with traditional physiological measurements. Experimental …
that is not directly appreciable with traditional physiological measurements. Experimental …
Gravitational distribution of regional opening and closing pressures, hysteresis and atelectrauma in ARDS evaluated by electrical impedance tomography
G Scaramuzzo, E Spinelli, S Spadaro, A Santini… - Critical Care, 2020 - Springer
Background The physiological behavior of lungs affected by the acute respiratory distress
syndrome (ARDS) differs between inspiration and expiration and presents heterogeneous …
syndrome (ARDS) differs between inspiration and expiration and presents heterogeneous …
A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography
Background Typical features differentiate COVID-19-associated lung injury from acute
respiratory distress syndrome. The clinical role of chest computed tomography (CT) in …
respiratory distress syndrome. The clinical role of chest computed tomography (CT) in …
Prone Positioning and Molecular Biomarkers in COVID and Non-COVID ARDS: A Narrative Review
S Spadaro, JD Jimenez-Santana, R La Rosa… - Journal of Clinical …, 2024 - mdpi.com
Prone positioning (PP) represents a therapeutic intervention with the proven capacity of
ameliorating gas exchanges and ventilatory mechanics indicated in acute respiratory …
ameliorating gas exchanges and ventilatory mechanics indicated in acute respiratory …
The effect of positive end-expiratory pressure on lung micromechanics assessed by synchrotron radiation computed tomography in an animal model of ARDS
Modern ventilatory strategies are based on the assumption that lung terminal airspaces act
as isotropic balloons that progressively accommodate gas. Phase contrast synchrotron …
as isotropic balloons that progressively accommodate gas. Phase contrast synchrotron …
Capnodynamic end‐expiratory lung volume assessment in anesthetized healthy children
J Lundquist, N Shams, M Wallin, M Hallbäck… - Pediatric …, 2024 - Wiley Online Library
Background Capnodynamic lung function monitoring generates variables that may be useful
for pediatric perioperative ventilation. Aims Establish normal values for end‐expiratory lung …
for pediatric perioperative ventilation. Aims Establish normal values for end‐expiratory lung …
Biological impact of restrictive and liberal fluid strategies at low and high PEEP levels on lung and distal organs in experimental acute respiratory distress syndrome
NS Felix, LA Maia, NN Rocha, GC Rodrigues… - Frontiers in …, 2022 - frontiersin.org
Background: Fluid regimens in acute respiratory distress syndrome (ARDS) are conflicting.
The amount of fluid and positive end-expiratory pressure (PEEP) level may interact leading …
The amount of fluid and positive end-expiratory pressure (PEEP) level may interact leading …
Regional pleural strain measurements during mechanical ventilation using ultrasound elastography: A randomized, crossover, proof of concept physiologic study
M Girard, MH Roy Cardinal, M Chassé… - Frontiers in …, 2022 - frontiersin.org
Background Mechanical ventilation is a common therapy in operating rooms and intensive
care units. When ill-adapted, it can lead to ventilator-induced lung injury (VILI), which is …
care units. When ill-adapted, it can lead to ventilator-induced lung injury (VILI), which is …