Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Reversible acetylation of histone and non-histone proteins is one of the most abundant post-
translational modifications in eukaryotic cells. Protein acetylation and deacetylation are …

Histone deacetylase inhibitors (HDACis) have now emerged as a powerful new class of
small-molecule therapeutics acting through the regulation of the acetylation states of histone …

Reversible acetylation mediated by histone deacetylases (HDACs) influences a broad
repertoire of physiological processes, many of which are aberrantly controlled in tumor cells …

Histone deacetylases are key enzymes of epigenetic regulation and are therefore involved
in crucial cellular events like transcription, differentiation, apoptosis and cell division. The …

Objective Pancreatic cancer is characterised by invasive tumour spread and early
metastasis formation. During epithelial–mesenchymal transition, loss of the cell adhesion …

Background In breast cancer, the role of epigenetic alterations including modifications of the
acetylation status of histones in carcinogenesis has been an important research focus …

Simple Summary Multiple myeloma (MM) is a frequent hematological malignancy
characterized by the uncontrolled growth of clonal plasma cells, primarily in the bone …

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer worldwide
and in the United States. OSCC remains a major cause of morbidity and mortality in patients …

Highlights•Isoform-selective histone deacetylase inhibitors are highly desirable.•Crystal
structure information provides important insights into inhibitor selectivity.•We review the …