Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
Non-epithelial ovarian cancers: how much do we really know?
A Cheung, S Shah, J Parker, P Soor, A Limbu… - International Journal of …, 2022 - mdpi.com
Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly
includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely …
includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely …
Sexual dimorphism in cancer
A Clocchiatti, E Cora, Y Zhang, GP Dotto - Nature Reviews Cancer, 2016 - nature.com
The incidence of many types of cancer arising in organs with non-reproductive functions is
significantly higher in male populations than in female populations, with associated …
significantly higher in male populations than in female populations, with associated …
[HTML][HTML] Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer
H Shao, EM Mohamed, GG Xu, M Waters, K Jing… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cancer cells rely on hyperactive de novo lipid synthesis for maintaining malignancy. Recent
studies suggest involvement in cancer of fatty acid oxidation, a process functionally opposite …
studies suggest involvement in cancer of fatty acid oxidation, a process functionally opposite …
Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin
C Xu, WB Shen, EA Reece, H Hasuwa, C Harman… - Science …, 2021 - science.org
Neural tube defects (NTDs) are the second most common structural birth defect.
Senescence, a state of permanent cell cycle arrest, occurs only after neural tube closure …
Senescence, a state of permanent cell cycle arrest, occurs only after neural tube closure …
Androgen-induced miR-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression
Prostate cancer (PCa) is the most commonly diagnosed and secondly leading cause of
cancer death among males. But the precise mechanism of prostate cancer progression …
cancer death among males. But the precise mechanism of prostate cancer progression …
P21‐activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells
M Babagana, S Johnson, H Slabodkin… - Molecular …, 2017 - Wiley Online Library
BRAF is a commonly mutated oncogene in various human malignancies and a target of a
new class of anti‐cancer agents, BRAF‐inhibitors (BRAFi). The initial enthusiasm for these …
new class of anti‐cancer agents, BRAF‐inhibitors (BRAFi). The initial enthusiasm for these …
MicroRNA expression profiles in non‑epithelial ovarian tumors
RK Chang, X Li, N Mu… - International …, 2018 - spandidos-publications.com
Ovarian germ cell tumors (OGCTs) and sex cord stromal tumors (SCSTs) are rare
gynecologic tumors that are derived from germ and stromal cells, respectively. Unlike their …
gynecologic tumors that are derived from germ and stromal cells, respectively. Unlike their …
FoxO transcription factors 1 regulate mouse preimplantation embryo development
N Kuscu, NE Gungor-Ordueri, B Sozen… - Journal of assisted …, 2019 - Springer
Purpose The aim of the present study is to investigate role of FoxO transcription factors in
preimplantation embryo development by knocking down FoxO1, FoxO3, and FoxO4 genes …
preimplantation embryo development by knocking down FoxO1, FoxO3, and FoxO4 genes …
Regulation of let-7a-5p and miR-199a-5p expression by Akt1 modulates prostate cancer epithelial-to-mesenchymal transition via the transforming growth factor-β …
Simple Summary The molecular mechanisms regulating the switch from the growth of tumor
cells to invasive phenotype for metastasis is largely unknown. Molecules such as Akt1 and …
cells to invasive phenotype for metastasis is largely unknown. Molecules such as Akt1 and …