Clustered miRNAs and their role in biological functions and diseases

SP Kabekkodu, V Shukla, VK Varghese… - Biological …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Non-epithelial ovarian cancers: how much do we really know?

A Cheung, S Shah, J Parker, P Soor, A Limbu… - International Journal of …, 2022 - mdpi.com
Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly
includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely …

Sexual dimorphism in cancer

A Clocchiatti, E Cora, Y Zhang, GP Dotto - Nature Reviews Cancer, 2016 - nature.com
The incidence of many types of cancer arising in organs with non-reproductive functions is
significantly higher in male populations than in female populations, with associated …

[HTML][HTML] Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

H Shao, EM Mohamed, GG Xu, M Waters, K Jing… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cancer cells rely on hyperactive de novo lipid synthesis for maintaining malignancy. Recent
studies suggest involvement in cancer of fatty acid oxidation, a process functionally opposite …

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin

C Xu, WB Shen, EA Reece, H Hasuwa, C Harman… - Science …, 2021 - science.org
Neural tube defects (NTDs) are the second most common structural birth defect.
Senescence, a state of permanent cell cycle arrest, occurs only after neural tube closure …

Androgen-induced miR-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression

X Wan, W Huang, S Yang, Y Zhang, P Zhang… - The international journal …, 2016 - Elsevier
Prostate cancer (PCa) is the most commonly diagnosed and secondly leading cause of
cancer death among males. But the precise mechanism of prostate cancer progression …

P21‐activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells

M Babagana, S Johnson, H Slabodkin… - Molecular …, 2017 - Wiley Online Library
BRAF is a commonly mutated oncogene in various human malignancies and a target of a
new class of anti‐cancer agents, BRAF‐inhibitors (BRAFi). The initial enthusiasm for these …

MicroRNA expression profiles in non‑epithelial ovarian tumors

RK Chang, X Li, N Mu… - International …, 2018 - spandidos-publications.com
Ovarian germ cell tumors (OGCTs) and sex cord stromal tumors (SCSTs) are rare
gynecologic tumors that are derived from germ and stromal cells, respectively. Unlike their …

FoxO transcription factors 1 regulate mouse preimplantation embryo development

N Kuscu, NE Gungor-Ordueri, B Sozen… - Journal of assisted …, 2019 - Springer
Purpose The aim of the present study is to investigate role of FoxO transcription factors in
preimplantation embryo development by knocking down FoxO1, FoxO3, and FoxO4 genes …

Regulation of let-7a-5p and miR-199a-5p expression by Akt1 modulates prostate cancer epithelial-to-mesenchymal transition via the transforming growth factor-β …

A Alwhaibi, V Parvathagiri, A Verma, S Artham, MS Adil… - Cancers, 2022 - mdpi.com
Simple Summary The molecular mechanisms regulating the switch from the growth of tumor
cells to invasive phenotype for metastasis is largely unknown. Molecules such as Akt1 and …