Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …

Construction of a bispecific single-chain antibody derivative is described that consists of two
different single-chain Fv fragments joined through a Gly-Ser linker. One specificity of the two …

Alteration of the natural tropism of adenovirus (Ad) will permit gene transfer into specific cell
types and thereby greatly broaden the scope of target diseases that can be treated by using …

Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is
insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response. In the …

Natural killer (NK) cells are members of the innate immune system that recognize target cells
via activating and inhibitory signals received through cell receptors. Derived from the …

Tumor immunotherapy should increase both the number of T cells that kill the tumor and the
likelihood that those cells are activated at the tumor site. Bispecific monoclonal antibodies …

Receptors used by natural killer (NK) cells to mediate natural cytotoxicity are poorly defined,
although it is now clear that a number of adhesion molecules can serve this function. CD38 …

T cells are primary targets in numerous gene therapy protocols. However, the use of
subgroup C adenovirus serotype 2 or 5 (Ad2 or Ad5) as a vector to transduce T cells is …

In order to target NK cells against the Hodgkin's‐derived cell line L540, we developed
bispecific monoclonal antibodies (Bi‐MAbs) by somatic hybridization of the 2 mouse …

CD 16 surface antigens represent activatory molecules in CD3–16+ NK cells. In order to
target NK cells against relatively NK‐resistant ovarian carcinomas, we used an anti‐CD 16 …