Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …

Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease of the central
nervous system (CNS) characterized by acute optic neuritis (ON) and transverse myelitis …

Triggering receptor expressed on myeloid cells 2 (TREM2) is strongly linked to Alzheimer's
disease (AD) risk, but its functions are not fully understood. Here, we found that TREM2 …

Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Excessive inflammatory responses contribute to the pathogenesis and lethality of highly
pathogenic human coronaviruses, but the underlying mechanism remains unclear. In this …

The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …

When nanoparticles are intravenously injected into the body, complement proteins deposit
on the surface of nanoparticles in a process called opsonization. These proteins prime the …

The complement system is an important part of the innate immune defence. It contributes not
only to local inflammation, removal and killing of pathogens, but it also assists in shaping of …

In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …