[HTML][HTML] Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review

A Hosseini, H Hosseinzadeh - Biomedicine & pharmacotherapy, 2018 - Elsevier
Curcuma longa is a rhizomatous perennial herb that belongs to the family Zingiberaceae,
native to South Asia and is commonly known as turmeric. It is used as herbal remedy due to …

Polyphenols: Major regulators of key components of DNA damage response in cancer

M Majidinia, A Bishayee, B Yousefi - DNA repair, 2019 - Elsevier
DNA fidelity is constantly endangered by various types of intrinsic damages and extrinsic
damages. Cells that are affected by DNA damage employ a specific, intricate, and …

Amyotrophic lateral sclerosis and oxidative stress: a double-blind therapeutic trial after curcumin supplementation

L Chico, EC Ienco, C Bisordi, A Lo Gerfo… - CNS & Neurological …, 2018 - ingentaconnect.com
Objective: To investigate the efficacy of curcumin oral supplementation (600 mg/day,
Brainoil), a natural antioxidant compound, in Amyotrophic Lateral Sclerosis (ALS). Methods …

Ameliorating potential of curcumin and its analogue in central nervous system disorders and related conditions: a review of molecular pathways

P Joshi, A Bisht, S Joshi, D Semwal… - Phytotherapy …, 2022 - Wiley Online Library
Curcumin, isolated from turmeric (Curcuma longa L.) is one of the broadly studied
phytomolecule owing to its strong antioxidant and anti‐inflammatory potential and has been …

Therapeutic role of curcumin in diabetes: an analysis based on bioinformatic findings

A Mahmoudi, SL Atkin, NG Nikiforov, A Sahebkar - Nutrients, 2022 - mdpi.com
Background: Diabetes is an increasingly prevalent global disease caused by the impairment
in insulin production or insulin function. Diabetes in the long term causes both microvascular …

Add-on treatment with curcumin has antidepressive effects in Thai patients with major depression: results of a randomized double-blind placebo-controlled study

B Kanchanatawan, S Tangwongchai… - Neurotoxicity …, 2018 - Springer
Activation of immune-inflammatory and oxidative-nitrosative (IO&NS) stress pathways plays
a role in major depression (MDD). Evidence suggests that curcumin (500–1000 mg/day), a …

A comprehensive review of mechanistic insights into formaldehyde-induced nasal cavity carcinogenicity

A Nishikawa, K Nagano, H Kojima, K Ogawa - Regulatory Toxicology and …, 2021 - Elsevier
Abstract According to the International Agency for Research on Cancer classification,
formaldehyde is a human carcinogen that targets the nasal cavity. In humans and rats …

Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCδ

B Yang, C Yin, Y Zhou, Q Wang, Y Jiang, Y Bai, H Qian… - Toxicology, 2019 - Elsevier
Methylmercury (MeHg) is a ubiquitous environmental toxicant that leads to long-lasting
neurological deficits in animals and humans. Curcumin, a polyphenol obtained from the …

Genome-protecting compounds as potential geroprotectors

E Proshkina, M Shaposhnikov, A Moskalev - International journal of …, 2020 - mdpi.com
Throughout life, organisms are exposed to various exogenous and endogenous factors that
cause DNA damages and somatic mutations provoking genomic instability. At a young age …

Preemptive analgesic and antioxidative effect of curcumin for experimental migraine

AE Bulboacă, SD Bolboacă, IC Stănescu… - BioMed Research …, 2017 - Wiley Online Library
Objective. Our study aimed to investigate the analgesic and antioxidative stress effects of
Curcumin (CC) in experimental migraine induced by Nitroglycerin (NTG) on rats, compared …