UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and
a non-specific damaging agent and has properties of both a tumor initiator and a tumor …

The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …

DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …

All cancers carry somatic mutations. A subset of these somatic alterations, termed driver
mutations, confer selective growth advantage and are implicated in cancer development …

UV-radiations are the invisible part of light spectra having a wavelength between visible rays
and X-rays. Based on wavelength, UV rays are subdivided into UV-A (320–400 nm), UV-B …

Somatic mutations are the driving force of cancer genome evolution. The rate of somatic
mutations appears to be greatly variable across the genome due to variations in chromatin …

Somatic mutations in human cancers show unevenness in genomic distribution that
correlate with aspects of genome structure and function. These mutations are, however …

Ovarian cancer has poor survival rates due to a combination of diagnosis at advanced
disease stages and disease recurrence as a result of platinum chemotherapy resistance …

We performed exome sequencing to detect somatic mutations in protein-coding regions in
seven melanoma cell lines and donor-matched germline cells. All melanoma samples had …

Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are
particularly caused by endogenously produced reactive compounds such as formaldehyde …