Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD),
both in the USA and in Europe; moreover, its incidence is rising worldwide. The main …

Growth hormone (GH) and its mediator insulin-like growth factor-1 (IGF-1) have manifold
effects on the kidneys. GH and IGF receptors are abundantly expressed in the kidney …

Diabetic kidney disease (DKD) is one of the leading causes of death among patients
diagnosed with diabetes mellitus. Despite the growing knowledge about the pathogenesis of …

Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either
directly or via its main mediator, insulin-like-growth factor-1 (IGF-1). The GH/IGF1 system …

The understanding of renal fibrosis in chronic kidney disease (CKD) remains as a challenge.
More than 10% of the population of developed countries suffer from CKD. Proliferation and …

Glomerular podocytes are integral members of the glomerular filtration barrier in the kidney
and are crucial for glomerular permselectivity. These highly differentiated cells are …

Growth hormone (GH) plays a significant role in normal renal function and overactive GH
signaling has been implicated in proteinuria in diabetes and acromegaly. Previous results …

Context Previous studies have implicated growth hormone (GH) in the progression of
several cancers, including breast, colorectal, and pancreatic. A mechanism by which GH …

OBJECTIVE Chronic kidney disease (CKD) in diabetes has a complex molecular and likely
multifaceted pathophysiology. We aimed to validate a panel of biomarkers identified using a …

Pituitary growth hormone (GH) is essential for growth, metabolism, and renal function.
Overactive GH signaling is associated with impaired kidney function. Glomerular podocytes …