One of the most salient features of Bacillus subtilis and related bacilli is their natural capacity
to secrete a variety of proteins into their environment, frequently to high concentrations. This …

The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …

Overexpression of membrane proteins is often essential for structural and functional studies,
but yields are frequently too low. An understanding of the physiological response to …

In Escherichia coli, both secretory and inner membrane proteins initially are targeted to the
core SecYEG inner membrane translocase. Previous work has also identified the …

Escherichia coli is one of the most widely used vehicles to overexpress membrane proteins
(MPs). Currently, it is not possible to predict if an overexpressed MP will end up in the …

YidC of Echerichia coli, a member of the conserved Alb3/Oxa1/YidC family, is postulated to
be important for biogenesis of membrane proteins. Here, we use as a model the lactose …

Integral membrane proteins are found in all cellular membranes and carry out many of the
functions that are essential to life. The membrane-embedded domains of integral membrane …

The YidC/Alb3/Oxa1 family functions in the insertion and folding of proteins in the bacterial
cytoplasmic membrane, the chloroplast thylakoid membrane, and the mitochondrial inner …

In bacteria, the translocase mediates the translocation of proteins into or across the cytosolic
membrane. It consists of a membrane embedded protein-conducting channel and a …

Abstract The membrane insertases YidC–Oxa1–Alb3 provide a simple cellular system that
catalyzes the transmembrane topology of newly synthesized membrane proteins. The …