Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and
neuronal death are commonly found in the brains of patients with clinical Parkinson disease …

The versatility of mitochondrial metabolism and its fine adjustments to specific physiological
or pathological conditions regulate fundamental cell pathways, ranging from proliferation to …

Alterations in α-synuclein dosage lead to familial Parkinson's disease (PD), and its
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …

Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …

Parkinson disease (PD) is a multifactorial neurodegenerative disorder, the etiology of which
remains largely unknown. Progressive impairment of voluntary motor control, which …

As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …

Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis with
associated frontotemporal dementia (ALS/FTD) are major neurodegenerative diseases for …

Abstract α-Synuclein is strongly linked to Parkinson's disease but the molecular targets for its
toxicity are not fully clear. However, many neuronal functions damaged in Parkinson's …