Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …

The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …

Since their discovery in the 1960s, the family of Fe (II)/2-oxoglutarate-dependent
oxygenases has undergone a tremendous expansion to include enzymes catalyzing a vast …

THE PAST TWO DECADES have brought remarkable progress in our understanding of the
molecular basis of hemophilia A. This disease, which has already been documented as a …

This article addresses the role of platelet membrane phosphatidylserine (PS) in regulating
the production of thrombin, the central regulatory molecule of blood coagulation. PS is …

Blood coagulation is initiated when tissue factor binds to coagulation factor Vila to give an
enzymatically active complex which then activates factors IX and X, leading to thrombin …

The nuclear magnetic resonance structure of a covalently linked pair of calcium-binding (cb)
epidermal growth factor-like (EGF) domains from human fibrillin-1, the protein defective in …

This review focuses on selected areas that should interest both the scientist and the clinician
alike: polymorphisms within the factor VIII and factor IX genes, their linkage, and their ethnic …

Cancer, cardiovascular disease, and infectious diseases are all global health threats. To
combat these diseases with gene therapies, adenovirus-based vectors have been …