Abstract Jun: Fos and Jun: ATF complexes represent two classes of AP-1 dimers that (1)
preferentially bind to either heptameric or octameric AP-1 binding sites, and (2) are …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

Abstract Cellular Jun (c-Jun) and viral Jun (v-Jun) can induce oncogenic transformation. For
this activity, c-Jun requires an upstream signal, delivered by the Jun N-terminal kinase …

The checkpoint kinase 1 (Chk1) preserves genome integrity when replication is performed
on damaged templates. Recently, Chk1 has also been implicated in regulating different …

The oncogenic cellular phenotype reflects transcriptional and post-transcriptional changes
in gene expression. The popular technique of expression profiling with microarrays …

In some situations, cell death in the nervous system is controlled by an interplay between
survival factors and negative survival signals that actively induce apoptosis. The present …

Cellular transformation can be achieved by constitutive activation of growth-regulatory
signaling pathways, which, in turn, activate nuclear transcription factors thought to execute a …

The duration of ERK1/2 activation influences the nature of the biological response to
agonist. Members of the AP-1 transcription factor family are well known targets of the …

Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of
Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in …

We have used chicken cDNA microarrays to investigate gene-expression changes induced
during transformation of chick embryo fibroblasts (CEF) by the viral Jun oncoprotein …