Myriad DNA-binding proteins undergo dynamic assembly, translocation, and conformational
changes while on DNA or alter the physical configuration of the DNA substrate to control its …

Understanding the function of eukaryotic genomes, including the human genome, is
undoubtedly one of the major scientific challenges of the 21st century. The cornerstone of …

Eukaryotic nuclei are constantly being exposed to factors that break or chemically modify the
DNA. Accurate repair of this DNA damage is crucial to prevent DNA mutations and maintain …

During replication, expression, and repair of the eukaryotic genome, cellular machinery must
access the DNA wrapped around histone proteins forming nucleosomes. These octameric …

Chromatin replication involves the assembly and activity of the replisome within the
nucleosomal landscape. At the core of the replisome is the Mcm2-7 complex (MCM), which …

The ability to accurately map the 3D geometry of single-molecule complexes in trace
samples is a challenging goal that would lead to new insights into molecular mechanics and …

The conformational dynamics of nucleosome arrays generate a diverse spectrum of
microscopic states, posing challenges to their structural determination. Leveraging …

Chromatin homeostasis mediates essential processes in eukaryotes, where histone
chaperones have emerged as major regulatory factors during DNA replication, repair, and …

Multiple testis-specific histone variants are involved in the dynamic chromatin transitions
during spermatogenesis. H2B. W1 (previously called H2BFWT) is an H2B variant specific to …

The nucleosome including H2A. B, a mammalian-specific H2A variant, plays pivotal roles in
spermatogenesis, embryogenesis, and oncogenesis, indicating unique involvement in …