Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair

P Ahangar, SJ Mills, AJ Cowin - International journal of molecular …, 2020 - mdpi.com
The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is
currently of enormous interest. However, the broad translation of cell therapies into clinical …

Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells

M Sarsenova, Y Kim, K Raziyeva, B Kazybay… - Frontiers in …, 2022 - frontiersin.org
Considering the unique therapeutic potential of mesenchymal stem cells (MSCs), including
their immunosuppressive and immunomodulatory properties as well as their ability to …

Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling

KH Griffin, SW Fok, J Kent Leach - NPJ Regenerative Medicine, 2022 - nature.com
Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …

Exosomes secreted from induced pluripotent stem cell-derived mesenchymal stem cells accelerate skin cell proliferation

S Kim, SK Lee, H Kim, TM Kim - International journal of molecular …, 2018 - mdpi.com
Induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) serve as a
unique source for cell therapy. We investigated whether exosomes from iMSCs promote the …

Conditioned medium from human mesenchymal stromal cells: towards the clinical translation

G Sagaradze, O Grigorieva, P Nimiritsky… - International journal of …, 2019 - mdpi.com
Mesenchymal stem/stromal cells (MSC) remain a promising tool for regenerative medicine
as the efficacy of MSC-based cell therapy has been demonstrated for a broad spectrum of …

Mesenchymal Stromal Cell–Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils

C Wang, V Börger, M Sardari, F Murke, J Skuljec, R Pul… - Stroke, 2020 - Am Heart Assoc
Background and Purpose—Small extracellular vesicles (sEVs) obtained from mesenchymal
stromal cells (MSCs) were shown to induce neurological recovery after focal cerebral …

Bolstering the secretion and bioactivities of umbilical cord MSC-derived extracellular vesicles with 3D culture and priming in chemically defined media

JY Kim, WK Rhim, SG Cha, J Woo, JY Lee, CG Park… - Nano …, 2022 - Springer
Human mesenchymal stem cells (hMSCs)-derived extracellular vesicles (EVs) have been
known to possess the features of the origin cell with nano size and have shown therapeutic …

The impact of cryopreservation on bone marrow-derived mesenchymal stem cells: a systematic review

S Bahsoun, K Coopman, EC Akam - Journal of translational medicine, 2019 - Springer
Mesenchymal stem cells (MSCs) represent an invaluable asset for the field of cell therapy.
Human Bone marrow-derived MSCs (hBM-MSCs) are one of the most commonly used cell …

Therapeutic mesenchymal stem/stromal cells: value, challenges and optimization

M Najar, R Melki, F Khalife, L Lagneaux… - Frontiers in cell and …, 2022 - frontiersin.org
Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …