Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

Cells in our body interact with their environment by a large group of diverse cell adhesion
molecules (CAMs). CAMs are involved in intercellular, intracellular, and cell-extra-cellular …

Acute lung injury, referred to as the acute chest syndrome, is a major cause of morbidity and
mortality in patients with sickle cell disease (SCD), which often occurs in the setting of a vaso …

Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by painful vaso-
occlusive crises (VOC) and chronic hemolysis. The mononuclear phagocyte system is …

As a consequence of tissue injury or infection, neutrophils are recruited in a stepwise
recruitment process from the bloodstream into the surrounding tissue. Selectins are a family …

Sickle cell anemia (SCA) is a genetic disease caused by the homozygosity of the HBB: c.
20A> T mutation, which results in the production of hemoglobin S (HbS). In hypoxic …

Venous thromboembolism (VTE) is an important cause of vascular morbidity and mortality.
Many risk factors have been identified for venous thrombosis that lead to alterations in blood …

Microvascular vaso-occlusion driven pain crisis is the hallmark of sickle cell disease with
profound morbidity and increased mortality. Selectins, most notably P-selectins have an …

Sickle cell disease (SCD)-associated chronic hemolysis promotes oxidative stress,
inflammation, and thrombosis leading to organ damage, including liver damage …

Sickle cell disease (SCD) is caused by a homozygous mutation in the β-globin gene, which
leads to erythrocyte sickling, vasoocclusion, and intense hemolysis. P-selectin inhibition has …