Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner,
yet little is known about their roles in lineage commitment. Here, we identified Braveheart …

Rationale: Recent advances have improved our ability to generate cardiomyocytes from
human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) …

Generation of functional organs from patients' own cells is one of the ultimate goals of
regenerative medicine. As a novel approach to creation of organs from pluripotent stem cells …

A reliable source of human hepatocytes and transplantable livers is needed. Interspecies
embryo complementation, which involves implanting donor human stem cells into early …

Mouse epiblast stem cells (EpiSCs) display temporal differences in the upregulation of Mixl1
expression during the initial steps of in vitro differentiation, which can be correlated with their …

Human amniotic fluid stem cells (hAFSCs) harbor high proliferative capacity and high
differentiation potential and do not raise the ethical concerns associated with human …

Background Mesendoderm induction during embryonic stem cell (ESC) differentiation in
vitro is stimulated by the Transforming Growth Factor and Wingless (Wnt) families of growth …

We investigated the role of canonical WNT signaling in mesoderm and hematopoietic
development from human embryonic stem cells (hESCs) using a recombinant human …

Specific regulation of target genes by transforming growth factor-β (TGF-β) in a given cellular
context is determined in part by transcription factors and cofactors that interact with the Smad …

Abstract Development of transplantable engineered tissue has been hampered by lacking
vascular network within the engineered tissue. Three-dimensional (3D) printing has …