Traumatic brain injury (TBI) consists of acute and long-term pathophysiological sequelae
that ultimately lead to cognitive and motor function deficits, with age being a critical risk …

Heme oxygenase (HO) has both beneficial and detrimental effects via its metabolites,
including carbon monoxide (CO), biliverdin or bilirubin, and ferrous iron. HO-1 is an …

Acute central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI), and
spinal cord injury (SCI) present a grave health care challenge worldwide due to high …

The acute and chronic effects of traumatic brain injury (TBI) have been widely described;
however, there is limited knowledge on how a TBI sustained during early adulthood or mid …

The disruption of homeostasis of zinc (Zn2+) and copper (Cu2+) ions in the central nervous
system is involved in the pathogenesis of many neurodegenerative diseases, such as …

Repetitive mild traumatic brain injury (r-mTBI), commonly experienced by athletes and
military personnel, causes changes in multiple intracellular pathways, one of which involves …

Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which
there are currently no effective pharmacological treatment options. In this study then, we …

Metal dyshomeostasis is associated with neurodegenerative disorders, cancers and
vascular disease. We report the effects of age (range: 3 to 18 months) on regional copper …

Metal dyshomeostasis is a well-established consequence of neurodegenerative diseases
and traumatic brain injury. While the significance of metals continues to be uncovered in …

There are numerous blood-based biomarkers for assessing iron stores, but all come with
certain limitations. Hepcidin is a hormone primarily produced in the liver that has been …