Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

KD Davis, N Aghaeepour, AH Ahn, MS Angst… - Nature Reviews …, 2020 - nature.com
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

[HTML][HTML] Diabetic neuropathy: a position statement by the American Diabetes Association

R Pop-Busui, AJM Boulton, EL Feldman, V Bril… - Diabetes …, 2017 - ncbi.nlm.nih.gov
Diabetic neuropathies are the most prevalent chronic complications of diabetes. This
heterogeneous group of conditions affects different parts of the nervous system and presents …

Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management

TS Jensen, P Karlsson, SS Gylfadottir, ST Andersen… - Brain, 2021 - academic.oup.com
Peripheral neuropathy is one of the most common complications of both type 1 and type 2
diabetes. Up to half of patients with diabetes develop neuropathy during the course of their …

Peripheral neuropathy in diabetes mellitus: pathogenetic mechanisms and diagnostic options

R Galiero, A Caturano, E Vetrano, D Beccia… - International Journal of …, 2023 - mdpi.com
Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and
type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis …

The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes

AJ Terkelsen, P Karlsson, G Lauria, R Freeman… - The lancet …, 2017 - thelancet.com
Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated
Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre …

Peripheral neuropathy in prediabetes and the metabolic syndrome

AM Stino, AG Smith - Journal of diabetes investigation, 2017 - Wiley Online Library
Peripheral neuropathy is a major cause of disability worldwide. Diabetes is the most
common cause of neuropathy, accounting for 50% of cases. Over half of people with …

Diagnostic criteria for small fibre neuropathy in clinical practice and research

G Devigili, S Rinaldo, R Lombardi, D Cazzato… - Brain, 2019 - academic.oup.com
The diagnostic criteria for small fibre neuropathy are not established, influencing the
approach to patients in clinical practice, their access to disease-modifying and symptomatic …

The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy

AC Themistocleous, JD Ramirez, PR Shillo, JG Lees… - Pain, 2016 - journals.lww.com
Disabling neuropathic pain (NeuP) is a common sequel of diabetic peripheral neuropathy
(DPN). We aimed to characterise the sensory phenotype of patients with and without NeuP …

Metabolic syndrome and peripheral neuropathy

M Kazamel, AM Stino, AG Smith - Muscle & Nerve, 2021 - Wiley Online Library
Diabetic peripheral neuropathy and metabolic syndrome (MetS) are both global health
challenges with well‐established diagnostic criteria and significant impacts on quality of life …

Advances in screening, early diagnosis and accurate staging of diabetic neuropathy

J Carmichael, H Fadavi, F Ishibashi… - Frontiers in …, 2021 - frontiersin.org
The incidence of both type 1 and type 2 diabetes is increasing worldwide. Diabetic
peripheral neuropathy (DPN) is among the most distressing and costly of all the chronic …