The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …

Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

The oligonucleotide therapeutics field has seen remarkable progress over the last few years
with the approval of the first antisense drug and with promising developments in late stage …

Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …

Phosphorothioates have found their usefulness in the general area of oligonucleotide
therapeutic applications. Initially this modification was introduced into the antisense …

Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to
recognize a homologous mRNA sequence in the cell and induce its degradation. The main …

NF-κB is a key regulator of inflammation and cancer progression, with an important role in
leukemogenesis. Despite its therapeutic potential, targeting NF-κB using pharmacologic …

Purpose: Recent advances in immunotherapy of advanced human cancers underscored the
need to address and eliminate tumor immune evasion. The myeloid-derived suppressor …

Intracellular therapeutic targets that define tumor immunosuppression in both tumor cells
and T cells remain intractable. Here, we have shown that administration of a covalently …

How to effectively transform the pro-oncogenic tumor microenvironments (TME) surrounding
a tumor into an anti-tumoral never fails to attract people to study. Small interfering RNA …