The global nephrology community recognises the need for a cohesive plan to address the
problem of chronic kidney disease (CKD). In July, 2016, the International Society of …

Chronic kidney disease is defined as a reduced glomerular filtration rate, increased urinary
albumin excretion, or both, and is an increasing public health issue. Prevalence is estimated …

In the past decade, kidney disease diagnosed with objective measures of kidney damage
and function has been recognised as a major public health burden. The population …

Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …

The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed
cytoplasmic myosin that participates in a variety of processes requiring the generation of …

Background Among patients in the United States with chronic kidney disease, black patients
are at increased risk for end-stage renal disease, as compared with white patients. Methods …

African Americans have higher rates of kidney disease than European Americans. Here, we
show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and …

Focal segmental glomerulosclerosis, which is characterized by progressive glomerular
scarring, accounts for about 20% of cases of the nephrotic syndrome in children and 40% in …

Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney
disease in African Americans, but whether APOL1-associated glomerular disease has a …

The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …