Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

The proliferative activity of tumour cells represents an important prognostic marker in the
diagnosis of cancer. One of the methods for assessing the proliferative activity of cells is the …

Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

The cell-cycle transition from G 1 to S phase has been difficult to visualize. We have
harnessed antiphase oscillating proteins that mark cell-cycle transitions in order to develop …

▪ Abstract The maintenance of the eukaryotic genome requires precisely coordinated
replication of the entire genome each time a cell divides. To achieve this coordination …

Evidence obtained from studies with yeast and Xenopusindicate that the initiation of DNA
replication is a multistep process. The origin recognition complex (ORC), Cdc6p, and …

The minichromosome maintenance (or MCM) protein family is composed of six related
proteins that are conserved in all eukaryotes. They were first identified by genetic screens in …

BACKGROUND Cellular life depends on the ability of organisms to accurately duplicate and
transmit genetic information between generations. In bacteria, archaea, and eukaryotes, this …

In all eukaryotic organisms, inappropriate firing of replication origins during the G2 phase of
the cell cycle is suppressed by cyclin-dependent kinases. Multicellular eukaryotes contain a …