Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …

Background Cerebral ischemia–reperfusion (I/R) injury is a major cause of early
complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in …

Anti-programmed cell death protein 1 (PD-1) therapy is a standard of care in recurrent
metastatic head and neck squamous cell carcinoma (RMHNSCC). Vascular endothelial …

Background Neuropathic pain is a common and severely disabling state that affects millions
of people worldwide. Microglial activation in the spinal cord plays a critical role in the …

Tissue engineering biomaterials are aimed to mimic natural tissue and promote new tissue
formation for the treatment of impaired or diseased tissues. Highly porous biomaterial …

Alzheimer's disease (AD) is a complex neurodegenerative disorder. The pathology is
characterized by the generation of amyloid plaques and neuronal fiber tangles in the brain …

Among the multiple kinds of neuronal cell death triggered by traumatic brain injury (TBI),
ferroptosis, an iron-dependent lipid peroxidative regulatory cell death, has a critical role …

Although traumatic brain injury (TBI) is a common cause of death and disability worldwide,
there is currently a lack of effective therapeutic drugs and targets. To reveal the complex …

Although stem cell-derived extracellular vesicles (EVs) have remarkable therapeutic
potential for various diseases, the therapeutic efficacy of EVs is limited due to their …