The growing impact of catalysis in the pharmaceutical industry

CA Busacca, DR Fandrick, JJ Song… - Advanced Synthesis …, 2011 - Wiley Online Library
Catalysis has become increasingly important for the pharmaceutical industry. Catalysis is a
critical technology that enables economical and environmentally‐sound manufacturing …

Iminium catalysis

A Erkkilä, I Majander, PM Pihko - Chemical Reviews, 2007 - ACS Publications
This review covers reactions where iminium ions are likely to be active intermediates in the
catalytic cycle. The focus of the review is on synthetically useful protocols and smallmolecule …

Flow chemistry: recent developments in the synthesis of pharmaceutical products

R Porta, M Benaglia, A Puglisi - Organic Process Research & …, 2016 - ACS Publications
Recently, application of the flow technologies for the preparation of fine chemicals, such as
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …

Asymmetric aminocatalysis—gold rush in organic chemistry

P Melchiorre, M Marigo, A Carlone… - Angewandte Chemie …, 2008 - Wiley Online Library
Catalysis with chiral secondary amines (asymmetric aminocatalysis) has become a well‐
established and powerful synthetic tool for the chemo‐and enantioselective functionalization …

Cinchona‐based primary amine catalysis in the asymmetric functionalization of carbonyl compounds

P Melchiorre - Angewandte Chemie International Edition, 2012 - Wiley Online Library
Asymmetric aminocatalysis exploits the potential of chiral primary and secondary amines to
catalyze asymmetric reactions. It has greatly simplified the functionalization of carbonyl …

Asymmetric organocatalysis in total synthesis–a trial by fire

E Marqués-López, RP Herrera… - Natural Product …, 2010 - pubs.rsc.org
Covering: 2007 to 2009 This review covers the most recent applications of organocatalysis
in the synthesis of natural products and non-natural biologically active molecules. Our aim is …

Die asymmetrische Aminokatalyse–Goldrausch in der organischen Chemie

P Melchiorre, M Marigo, A Carlone… - Angewandte …, 2008 - Wiley Online Library
Die Katalyse mit chiralen sekundären Aminen (asymmetrische Aminokatalyse) ist ein
leistungsfähiges Verfahren zur chemo‐und enantioselektiven Funktionalisierung von …

One-Pot Enantioselective Synthesis of Functionalized Pyranocoumarins and 2-Amino-4H-chromenes: Discovery of a Type of Potent Antibacterial Agent

G Zhang, Y Zhang, J Yan, R Chen… - The Journal of …, 2012 - ACS Publications
Function-oriented design and synthesis of chiral small molecules with novel activity is a key
goal in modern organic chemistry. As multiple antibiotic-resistant pathogens are emerging …

Recent applications of Cinchona alkaloids and their derivatives as catalysts in metal-free asymmetric synthesis

EMO Yeboah, SO Yeboah, GS Singh - Tetrahedron, 2011 - Elsevier
The Cinchona alkaloids are natural products found in the bark of trees of the genus
Cinchona. The genus comprises about 40 species of trees or shrubs in the family Rubiaceae …

Organocatalytic asymmetric Friedel− Crafts alkylation of indoles with simple α, β-unsaturated ketones

G Bartoli, M Bosco, A Carlone, F Pesciaioli… - Organic …, 2007 - ACS Publications
The first general and highly enantioselective organocatalytic Friedel− Crafts alkylation of
indoles with simple α, β-unsaturated ketones has been accomplished. Central to these …