Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W Xiao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

The arms race between bacteria and their phage foes

HG Hampton, BNJ Watson, PC Fineran - Nature, 2020 - nature.com
Bacteria are under immense evolutionary pressure from their viral invaders—
bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and …

Bacteriophages inhibit and evade cGAS-like immune function in bacteria

E Huiting, X Cao, J Ren, JS Athukoralage, Z Luo… - Cell, 2023 - cell.com
A fundamental strategy of eukaryotic antiviral immunity involves the cGAS enzyme, which
synthesizes 2′, 3′-cGAMP and activates the effector STING. Diverse bacteria contain …

Mechanisms and clinical importance of bacteriophage resistance

JE Egido, AR Costa… - FEMS microbiology …, 2022 - academic.oup.com
We are in the midst of a golden age of uncovering defense systems against bacteriophages.
Apart from the fundamental interest in these defense systems, and revolutionary applications …

[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy

MF Rasul, BM Hussen, A Salihi, BS Ismael, PJ Jalal… - Molecular Cancer, 2022 - Springer
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity

SJ Hobbs, T Wein, A Lu, BR Morehouse, J Schnabel… - Nature, 2022 - nature.com
The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine
cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse …

The biology of CRISPR-Cas: backward and forward

F Hille, H Richter, SP Wong, M Bratovič, S Ressel… - Cell, 2018 - cell.com
In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …

Diverse enzymatic activities mediate antiviral immunity in prokaryotes

L Gao, H Altae-Tran, F Böhning, KS Makarova, M Segel… - Science, 2020 - science.org
Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements
and rely on dedicated antiviral defense systems, such as restriction endonucleases and …

Plasmid transfer by conjugation in Gram-negative bacteria: from the cellular to the community level

C Virolle, K Goldlust, S Djermoun, S Bigot, C Lesterlin - Genes, 2020 - mdpi.com
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …

Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing

BA Adler, T Hessler, BF Cress, A Lahiri, VK Mutalik… - Nature …, 2022 - nature.com
CRISPR-Cas13 proteins are RNA-guided RNA nucleases that defend against incoming
RNA and DNA phages by binding to complementary target phage transcripts followed by …