Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
The arms race between bacteria and their phage foes
HG Hampton, BNJ Watson, PC Fineran - Nature, 2020 - nature.com
Bacteria are under immense evolutionary pressure from their viral invaders—
bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and …
bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and …
Bacteriophages inhibit and evade cGAS-like immune function in bacteria
E Huiting, X Cao, J Ren, JS Athukoralage, Z Luo… - Cell, 2023 - cell.com
A fundamental strategy of eukaryotic antiviral immunity involves the cGAS enzyme, which
synthesizes 2′, 3′-cGAMP and activates the effector STING. Diverse bacteria contain …
synthesizes 2′, 3′-cGAMP and activates the effector STING. Diverse bacteria contain …
Mechanisms and clinical importance of bacteriophage resistance
JE Egido, AR Costa… - FEMS microbiology …, 2022 - academic.oup.com
We are in the midst of a golden age of uncovering defense systems against bacteriophages.
Apart from the fundamental interest in these defense systems, and revolutionary applications …
Apart from the fundamental interest in these defense systems, and revolutionary applications …
[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …
9) shows the opportunity to treat a diverse array of untreated various genetic and …
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity
The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine
cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse …
cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse …
The biology of CRISPR-Cas: backward and forward
F Hille, H Richter, SP Wong, M Bratovič, S Ressel… - Cell, 2018 - cell.com
In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
Diverse enzymatic activities mediate antiviral immunity in prokaryotes
Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements
and rely on dedicated antiviral defense systems, such as restriction endonucleases and …
and rely on dedicated antiviral defense systems, such as restriction endonucleases and …
Plasmid transfer by conjugation in Gram-negative bacteria: from the cellular to the community level
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …
Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing
CRISPR-Cas13 proteins are RNA-guided RNA nucleases that defend against incoming
RNA and DNA phages by binding to complementary target phage transcripts followed by …
RNA and DNA phages by binding to complementary target phage transcripts followed by …