Polyphosphate (polyP), a polymer of orthophosphate (PO4 3-) of varying lengths, has been
identified in all kingdoms of life. It can serve as a source of chemical bond energy …

Inorganic polyphosphates (polyP) consist of linear chains of orthophosphate residues,
linked by high-energy phosphoanhydride bonds. They are evolutionarily old biopolymers …

Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and
plant unicellular parasites. Understanding their complex cell architecture and life cycle is …

Chloroplasts are eukaryotic photosynthetic organelles that drive the global carbon cycle.
Despite their importance, our understanding of their protein composition, function, and …

The kinetoplastids Trypanosoma brucei and Leishmania mexicana are eukaryotes with a
highly structured cellular organisation that is reproduced with great fidelity in each …

There is no effective cure for Chagas disease, which is caused by infection with the
arthropod-borne parasite, Trypanosoma cruzi. In the search for new drugs to treat Chagas …

Methods for genetic manipulation of Trypanosoma cruzi, the etiologic agent of Chagas
disease, have been highly inefficient, and no endogenous tagging of genes has been …

Acidocalcisomes are organelles conserved during evolution and closely related to the so-
called volutin granules of bacteria and archaea, to the acidocalcisome-like vacuoles of …

Acidocalcisomes are organelles rich in polyphosphate and cations and acidified by proton
pumps. Although they have also been described in prokaryotes they have been better …

Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that
have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton …