Much of the genetic basis of complex traits is present on current genotyping products, but the
individual variants that affect the traits have largely not been identified. Several traditional …

Purpose Localised prostate cancer diagnosis and management is increasingly complex due
to its heterogeneous progression and prognostic subgroups. Pitfalls in current screening …

EFSA and EMA have jointly reviewed measures taken in the EU to reduce the need for and
use of antimicrobials in food‐producing animals, and the resultant impacts on antimicrobial …

Health systems are stewards of patient electronic health record (EHR) data with
extraordinarily rich depth and breadth, reflecting thousands of diagnoses and exposures …

Since their first appearance in the context of schizophrenia and bipolar disorder in 2009,
polygenic risk scores (PRSs) have been described for a large number of common complex …

Cancer encompasses a complex, heterogeneous and dynamic group of diseases that arise
from perturbations to multiple biological networks within the body. A systems biology-based …

PURPOSE Prostate cancer (PCa) is highly heritable. No validated PCa risk model currently
exists. We therefore sought to develop a genetic risk model that can provide personalized …

BACKGROUND Prostate cancer is the most common cancer among men in the UK. Prostate-
specific antigen testing followed by biopsy leads to overdetection, overtreatment as well as …

The diagnostics and management of localized prostate cancer is complicated because of
cancer heterogeneity and differentiated progression in various subgroups of patients. As a …

Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide
polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these …