Nuclease resistance of DNA nanostructures
AR Chandrasekaran - Nature Reviews Chemistry, 2021 - nature.com
DNA nanotechnology has progressed from proof-of-concept demonstrations of structural
design towards application-oriented research. As a natural material with excellent self …
design towards application-oriented research. As a natural material with excellent self …
Cell-free DNA and apoptosis: how dead cells inform about the living
E Heitzer, L Auinger, MR Speicher - Trends in molecular medicine, 2020 - cell.com
Cell-free DNA (cfDNA) is evolving into a widely used prognostic and predictive biomarker,
particularly in oncology. However, its versatile clinical use precedes a profound …
particularly in oncology. However, its versatile clinical use precedes a profound …
Polymer nano-systems for the encapsulation and delivery of active biomacromolecular therapeutic agents
M Machtakova, H Thérien-Aubin… - Chemical society …, 2022 - pubs.rsc.org
Biomacromolecular therapeutic agents, particularly proteins, antigens, enzymes, and nucleic
acids are emerging as powerful candidates for the treatment of various diseases and the …
acids are emerging as powerful candidates for the treatment of various diseases and the …
The life cycle of phagosomes: formation, maturation, and resolution
Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …
tissue homeostasis and is also an early, critical component of the innate immune response …
The biology of cell-free DNA fragmentation and the roles of DNASE1, DNASE1L3, and DFFB
Cell-free DNA (cf. DNA) is a powerful noninvasive biomarker for cancer and prenatal testing,
and it circulates in plasma as short fragments. To elucidate the biology of cf. DNA …
and it circulates in plasma as short fragments. To elucidate the biology of cf. DNA …
Apoptosis: controlled demolition at the cellular level
Apoptosis is characterized by a series of dramatic perturbations to the cellular architecture
that contribute not only to cell death, but also prepare cells for removal by phagocytes and …
that contribute not only to cell death, but also prepare cells for removal by phagocytes and …
Nucleic acid immunity
G Hartmann - Advances in immunology, 2017 - Elsevier
Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …
Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin
Cell-free DNA (cfDNA) in human plasma is a class of biomarkers with many current and
potential future diagnostic applications. Recent studies have shown that cfDNA molecules …
potential future diagnostic applications. Recent studies have shown that cfDNA molecules …
γH2AX and cancer
WM Bonner, CE Redon, JS Dickey… - Nature Reviews …, 2008 - nature.com
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …
What is stress? Concepts, definitions and applications in seed science
Summary 'Stresses' that impact upon seeds can affect plant reproduction and productivity,
and, hence, agriculture and biodiversity. In the absence of a clear definition of plant stress …
and, hence, agriculture and biodiversity. In the absence of a clear definition of plant stress …