Nuclease resistance of DNA nanostructures

AR Chandrasekaran - Nature Reviews Chemistry, 2021 - nature.com
DNA nanotechnology has progressed from proof-of-concept demonstrations of structural
design towards application-oriented research. As a natural material with excellent self …

Cell-free DNA and apoptosis: how dead cells inform about the living

E Heitzer, L Auinger, MR Speicher - Trends in molecular medicine, 2020 - cell.com
Cell-free DNA (cfDNA) is evolving into a widely used prognostic and predictive biomarker,
particularly in oncology. However, its versatile clinical use precedes a profound …

Polymer nano-systems for the encapsulation and delivery of active biomacromolecular therapeutic agents

M Machtakova, H Thérien-Aubin… - Chemical society …, 2022 - pubs.rsc.org
Biomacromolecular therapeutic agents, particularly proteins, antigens, enzymes, and nucleic
acids are emerging as powerful candidates for the treatment of various diseases and the …

The life cycle of phagosomes: formation, maturation, and resolution

R Levin, S Grinstein, J Canton - Immunological reviews, 2016 - Wiley Online Library
Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …

The biology of cell-free DNA fragmentation and the roles of DNASE1, DNASE1L3, and DFFB

DSC Han, M Ni, RWY Chan, VWH Chan, KO Lui… - The American Journal of …, 2020 - cell.com
Cell-free DNA (cf. DNA) is a powerful noninvasive biomarker for cancer and prenatal testing,
and it circulates in plasma as short fragments. To elucidate the biology of cf. DNA …

Apoptosis: controlled demolition at the cellular level

RC Taylor, SP Cullen, SJ Martin - Nature reviews Molecular cell biology, 2008 - nature.com
Apoptosis is characterized by a series of dramatic perturbations to the cellular architecture
that contribute not only to cell death, but also prepare cells for removal by phagocytes and …

Nucleic acid immunity

G Hartmann - Advances in immunology, 2017 - Elsevier
Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

K Sun, P Jiang, SH Cheng, THT Cheng… - Genome …, 2019 - genome.cshlp.org
Cell-free DNA (cfDNA) in human plasma is a class of biomarkers with many current and
potential future diagnostic applications. Recent studies have shown that cfDNA molecules …

γH2AX and cancer

WM Bonner, CE Redon, JS Dickey… - Nature Reviews …, 2008 - nature.com
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …

What is stress? Concepts, definitions and applications in seed science

I Kranner, FV Minibayeva, RP Beckett… - New Phytologist, 2010 - Wiley Online Library
Summary 'Stresses' that impact upon seeds can affect plant reproduction and productivity,
and, hence, agriculture and biodiversity. In the absence of a clear definition of plant stress …