Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

The distinct prion-like domains (PrLDs) of FUS and TDP-43, modulate phase transitions that
result in condensates with a range of material states. These assemblies are implicated in …

Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since
their discovery, there are several aspects that remain unexplored and, hence, poorly …

3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …

Protein aggregation is a feature of numerous neurodegenerative diseases. However,
regulated, often reversible, formation of protein aggregates, also known as condensates …

Covalent modifications to histones are essential for development, establishing distinct and
functional chromatin domains from a common genetic sequence. Whereas repressed …

Chromatin instability and protein homeostasis (proteostasis) stress are two well-established
hallmarks of aging, which have been considered largely independent of each other. Using …

Active accumulation of the data on new amyloids continuing nowadays dissolves
boundaries of the term “amyloid”. Currently, it is most often used to designate aggregates …

Stress granules are ribonucleoprotein assemblies that form in response to cellular stress.
Many of the RNA-binding proteins found in stress granule proteomes contain prion-like …

Infectious proteins or prions are a remarkable class of pathogens, where pathogenicity and
infectious state correspond to conformational transition of a protein fold. The conformational …