The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer's disease
Alzheimer's Disease (AD) is the most common form of dementia, affecting almost 50 million
of people around the world, characterized by a complex and age-related progressive …
of people around the world, characterized by a complex and age-related progressive …
Association of short-and long-latency afferent inhibition with human behavior
CV Turco, SL Toepp, SD Foglia, PW Dans… - Clinical …, 2021 - Elsevier
Transcranial magnetic stimulation (TMS) paired with nerve stimulation evokes short-latency
afferent inhibition (SAI) and long-latency afferent inhibition (LAI), which are non-invasive …
afferent inhibition (SAI) and long-latency afferent inhibition (LAI), which are non-invasive …
Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons
Synchronized activity in neural circuits, detected as oscillations in the extracellular field
potential, has been associated with learning and memory. Neural circuits in the basolateral …
potential, has been associated with learning and memory. Neural circuits in the basolateral …
Chrna2‐OLM interneurons display different membrane properties and h‐current magnitude depending on dorsoventral location
MM Hilscher, I Nogueira, S Mikulovic… - …, 2019 - Wiley Online Library
The hippocampus is an extended structure displaying heterogeneous anatomical cell layers
along its dorsoventral axis. It is known that dorsal and ventral regions show different integrity …
along its dorsoventral axis. It is known that dorsal and ventral regions show different integrity …
Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate
ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic …
ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic …
Quantitative properties of a feedback circuit predict frequency-dependent pattern separation
Feedback inhibitory motifs are thought to be important for pattern separation across species.
How feedback circuits may implement pattern separation of biologically plausible …
How feedback circuits may implement pattern separation of biologically plausible …
Exercise to spot the differences: a framework for the effect of exercise on hippocampal pattern separation in humans
L Jennen, V Mazereel, A Lecei, C Samaey… - Reviews in the …, 2022 - degruyter.com
Exercise has a beneficial effect on mental health and cognitive functioning, but the exact
underlying mechanisms remain largely unknown. In this review, we focus on the effect of …
underlying mechanisms remain largely unknown. In this review, we focus on the effect of …
Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits
In the hippocampus, episodic memories are thought to be encoded by the formation of
ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy …
ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy …
Gamma oscillations in the basolateral amygdala: biophysical mechanisms and computational consequences
The basolateral nucleus of the amygdala (BL) is thought to support numerous emotional
behaviors through specific microcircuits. These are often thought to be comprised of …
behaviors through specific microcircuits. These are often thought to be comprised of …
Neuronal degeneration impairs rhythms between connected microcircuits
SN Schumm, D Gabrieli, DF Meaney - Frontiers in computational …, 2020 - frontiersin.org
Synchronization of neural activity across brain regions is critical to processes that include
perception, learning, and memory. After traumatic brain injury (TBI), neuronal degeneration …
perception, learning, and memory. After traumatic brain injury (TBI), neuronal degeneration …