Pancreatic cancer is a leading cause of cancer death worldwide and its global burden has
more than doubled over the past 25 years. The highest incidence regions for pancreatic …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome.
Although the translation of circRNAs was reported, additional coding circRNAs and the …

Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing
unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma …

Background Risk factors for pancreatic cancer include a cluster of metabolic conditions such
as obesity, hypertension, dyslipidemia, insulin resistance, and type 2 diabetes. Given that …

Abstract In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe
and the United States combined. To identify common susceptibility alleles, we performed the …

Activation of the ATR kinase following perturbations to DNA replication relies on a complex
mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding …

Cancer from the gastrointestinal tract and its associated excretory organs will occur in more
than 300,000 Americans in 2017, with colorectal cancer responsible for> 40% of that …

The ATR checkpoint kinase coordinates cellular responses to DNA replication stress.
Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only …