[HTML][HTML] An ethical framework for human embryology with embryo models

NC Rivron, AM Arias, MF Pera, N Moris, HI M'hamdi - Cell, 2023 - cell.com
A human embryo's legal definition and its entitlement to protection vary greatly worldwide.
Recently, human pluripotent stem cells have been used to form in vitro models of early …

Early human embryonic development: Blastocyst formation to gastrulation

J Rossant, PPL Tam - Developmental cell, 2022 - cell.com
There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines

AT Clark, A Brivanlou, J Fu, K Kato, D Mathews… - Stem Cell Reports, 2021 - cell.com
Summary The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last
revised in 2016. Since then, rapid progress has been made in research areas related to in …

Opportunities and challenges with stem cell-based embryo models

J Rossant, PPL Tam - Stem Cell Reports, 2021 - cell.com
Stem cell-based embryo models open an unprecedented avenue for modeling
embryogenesis, cell lineage differentiation, tissue morphogenesis, and organogenesis in …

Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies

A Blasimme, J Sugarman - Cell Stem Cell, 2023 - cell.com
Human pluripotent stem cells can be used to derive in vitro models recapitulating post-
implantation human embryos. While useful for research purposes, such integrated embryo …

Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature

AS Iltis, G Koster, E Reeves, KRW Matthews - Stem Cell Research & …, 2023 - Springer
Recent advances in methods to culture pluripotent stem cells to model human development
have resulted in entities that increasingly have recapitulated advanced stages of early …

Technical challenges of studying early human development

PJ Rugg-Gunn, N Moris, PPL Tam - Development, 2023 - journals.biologists.com
Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

Ethical challenges in organoid use

V Mollaki - BioTech, 2021 - mdpi.com
Organoids hold great promises for numerous applications in biomedicine and
biotechnology. Despite its potential in science, organoid technology poses complex ethical …

Pluripotent Stem Cell-Derived In Vitro Gametogenesis and Synthetic Embryos—It Is Never Too Early for an Ethical Debate

S Horer, M Feichtinger, M Rosner… - Stem Cells …, 2023 - academic.oup.com
Recently, 2 branches of the wide area of synthetic biology—in vitro gametogenesis and
synthetic embryo development—have gained considerable attention. Rodent induced …

'Ceci n'est pas un embryon?'The ethics of human embryo model research

N de Graeff, L De Proost, M Munsie - Nature methods, 2023 - nature.com
‘Ceci n’est pas un embryon?’ The ethics of human embryo model research | Nature Methods
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