Mast cells (MCs) are tissue-resident immune cells that are important players in diseases
associated with chronic inflammation such as cancer. Since MCs can infiltrate solid tumors …

Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …

Alterations in metabolic pathways are a hallmark of cancer. A deeper understanding of the
contribution of different metabolites to carcinogenesis is thus vitally important to elucidate …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular
functions such as cell proliferation, migration, survival, calcium mobilization, cytoskeletal …

Lysophosphatidic acid receptor 1 (LPAR1) is elevated in breast cancer. The deregulation of
LPAR1, including the function and level of expression, is linked to cancer initiation …

Lipids are major actors and regulators of physiological processes within the lung. Initial
research has described their critical role in tissue homeostasis and in orchestrating cellular …

Lysophosphatidic acid (LPA) is an endogenous bioactive lipid that is produced
extracellularly and signals to cells via cognate LPA receptors, which are G‐protein coupled …

Pain associated with bone cancer remains poorly managed, and chemotherapeutic drugs
used to treat cancer usually increase pain. The discovery of dual-acting drugs that reduce …

Although immune checkpoint blockade (ICB) has become the mainstay of treatment for
advanced solid organ malignancies, success in revitalizing the host anticancer immune …

Lysophosphatidic acid receptors (LPARs) are six G-protein-coupled receptors that mediate
LPA signaling to promote tumorigenesis and therapy resistance in many cancer subtypes …