Brain organoids: advances, applications and challenges
Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …
[HTML][HTML] An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines
A Pérez-López, AI Torres-Suárez… - Advanced Drug Delivery …, 2023 - Elsevier
The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …
[HTML][HTML] A novel transwell blood brain barrier model using primary human cells
NL Stone, TJ England, SE O'Sullivan - Frontiers in cellular …, 2019 - frontiersin.org
Structural alterations and breakdown of the blood brain barrier (BBB) is often a primary or
secondary consequence of disease, resulting in brain oedema and the transport of …
secondary consequence of disease, resulting in brain oedema and the transport of …
Drug compound screening in single and integrated multi-organoid body-on-a-chip systems
Current practices in drug development have led to therapeutic compounds being approved
for widespread use in humans, only to be later withdrawn due to unanticipated toxicity …
for widespread use in humans, only to be later withdrawn due to unanticipated toxicity …
Emerging application of nanorobotics and artificial intelligence to cross the BBB: advances in design, controlled maneuvering, and targeting of the barriers
AV Singh, V Chandrasekar… - ACS chemical …, 2021 - ACS Publications
The blood–brain barrier (BBB) is a prime focus for clinicians to maintain the homeostatic
function in health and deliver the theranostics in brain cancer and number of neurological …
function in health and deliver the theranostics in brain cancer and number of neurological …
Recent advances in drug delivery and targeting to the brain
Our body keeps separating the toxic chemicals in the blood from the brain. A significant
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
Solid organ bioprinting: strategies to achieve organ function
AM Jorgensen, JJ Yoo, A Atala - Chemical Reviews, 2020 - ACS Publications
The field of tissue engineering has advanced over the past decade, but the largest impact on
human health should be achieved with the transition of engineered solid organs to the clinic …
human health should be achieved with the transition of engineered solid organs to the clinic …
Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform
Current drug development techniques are expensive and inefficient, partially due to the use
of preclinical models that do not accurately recapitulate in vivo drug efficacy and cytotoxicity …
of preclinical models that do not accurately recapitulate in vivo drug efficacy and cytotoxicity …
[HTML][HTML] In vitro modeling of the neurovascular unit: advances in the field
The blood–brain barrier (BBB) is a fundamental component of the central nervous system. Its
functional and structural integrity is vital in maintaining the homeostasis of the brain …
functional and structural integrity is vital in maintaining the homeostasis of the brain …
Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments
Glioblastoma is the deadliest form of brain cancer. Aside from inadequate treatment options,
one of the main reasons glioblastoma is so lethal is the rapid growth of tumour cells coupled …
one of the main reasons glioblastoma is so lethal is the rapid growth of tumour cells coupled …