The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

Many, if not most, embryos begin development with extremely short cell cycles that exhibit
unusually rapid DNA replication and no gap phases. The commitment to the cell cycle in the …

Transcription is an essential component of basic cellular and developmental processes.
However, early embryonic development occurs in the absence of transcription and instead …

The initial phases of embryonic development occur in the absence of de novo transcription
and are instead controlled by maternally inherited mRNAs and proteins. During this initial …

A gene's “expression profile” denotes the number of transcripts present relative to all other
transcripts. The overall rate of transcript production is determined by transcription and RNA …

The core machinery that drives the eukaryotic cell cycle has been thoroughly investigated
over the course of the past three decades. It is only more recently, however, that light has …

Background Fast, early embryonic cell cycles have correspondingly fast S phases. In early
Drosophila embryos, forks starting from closely spaced origins replicate the whole genome …

After fertilization, remodeling of the oocyte and sperm genomes is essential to convert these
highly differentiated and transcriptionally quiescent cells into early cleavage‐stage …

Understanding the mechanisms of embryonic cell cycles is a central goal of developmental
biology, as the regulation of the cell cycle must be closely coordinated with other events …

Extracellular signal-regulated kinase (Erk) signaling dynamics elicit distinct cellular
responses in a variety of contexts. The early zebrafish embryo is an ideal model to explore …