Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology
and neuroinflammation. Recently, there has been considerable interest in the role of …

The collapse of neural networks important for memory and cognition, including death of
neurons and degeneration of synapses, causes the debilitating dementia associated with …

Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several
neurodegenerative tauopathies including Alzheimer's disease (AD) and some …

A key knowledge gap blocking development of effective therapeutics for Alzheimer's disease
(AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of …

The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau
neurofibrillary tangles along with steady cognitive decline. Synaptic damage, an early …

Dysregulation of glutamatergic neural circuits has been implicated in a cycle of toxicity,
believed among the neurobiological underpinning of Alzheimer's disease. Previously, we …

Evidence suggests that amyloid β is highly toxic to synapses in a phospho-Tau-dependent
manner. Here, I present a hypothesis that links previous evidence from the first rise of …

Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau
neurofibrillary tangles along with steady cognitive decline. Although the mechanism by …

Alzheimer's disease (AD) is a progressive disorder in which the most noticeable symptoms
are cognitive impairment and memory loss. However, the precise mechanism by which …