Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19

AB Koopmans, MH Braakman, DJ Vinkers… - Translational …, 2021 - nature.com
Extensive migration has led to the necessity of knowledge regarding the treatment of
migrants with different ethnical backgrounds. This is especially relevant for pharmacological …

The future of personalized medicine in space: from observations to countermeasures

E Pavez Loriè, S Baatout, A Choukér… - … in bioengineering and …, 2021 - frontiersin.org
The aim of personalized medicine is to detach from a “one-size fits all approach” and
improve patient health by individualization to achieve the best outcomes in disease …

Polymorphism in CYP 2D6 and CYP 2C19, members of the cytochrome P450 mixed‐function oxidase system, in the metabolism of psychotropic drugs

J Stingl, R Viviani - Journal of internal medicine, 2015 - Wiley Online Library
Numerous studies in the field of psychopharmacological treatment have investigated the
possible contribution of genetic variability between individuals to differences in drug efficacy …

Pharmacogenetic tests to guide drug treatment in depression: comparison of the available testing kits and clinical trials

C Fabbri, J Zohar, A Serretti - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
The empirical approach to drug choice and dosing in depression often results into
inadequate response and side effects. Pharmacogenetic (PGx) testing appears a promising …

[HTML][HTML] A naturalistic study of the effectiveness of pharmacogenetic testing to guide treatment in psychiatric patients with mood and anxiety disorders

FX Brennan, KR Gardner, J Lombard… - The primary care …, 2015 - psychiatrist.com
Objective: To examine the effectiveness of genetic testing in a real-world setting and to
assess its impact on clinician treatment decisions. Method: This was a naturalistic …

The promise of psychiatric pharmacogenomics

SP Hamilton - Biological Psychiatry, 2015 - Elsevier
Clinicians already face “personalized” medicine every day while experiencing the great
variation in toxicities and drug efficacy among individual patients. Pharmacogenetics studies …

Pharmacogenetic testing of cytochrome P450 drug metabolizing enzymes in a case series of patients with Prader-Willi syndrome

J Forster, J Duis, MG Butler - Genes, 2021 - mdpi.com
Prader-Willi syndrome (PWS) is associated with co-morbid psychiatric symptoms (disruptive
behavior, anxiety, mood disorders, and psychosis) often requiring psychotropic medications …

Risperidone and venlafaxine metabolic ratios strongly predict a CYP2D6 poor metabolizing genotype

B Mannheimer, T Haslemo, JD Lindh… - Therapeutic drug …, 2016 - journals.lww.com
Purpose: To investigate the predictive value of the risperidone and venlafaxine metabolic
ratios and CYP2D6 genotype. Methods: The determination of risperidone, 9 …

Antidepressant pharmacogenetics

AB Singh, CA Bousman, C Ng… - Current opinion in …, 2014 - journals.lww.com
Early reports of clinical utility are published. The current evidence base for antidepressant
pharmacogenetics is, however, not yet empirically robust enough to inform routine …

Time in treatment: Examining mental illness trajectories across inpatient psychiatric treatment

H Oh, J Lee, S Kim, KA Rufino, P Fonagy… - Journal of psychiatric …, 2020 - Elsevier
Early discharge or reduced length of stay for inpatient psychiatric patients is related to
increased readmission rates and worse clinical outcomes including increased risk for …