Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein …

Genetic predisposition to multiple sclerosis (MS) only explains a fraction of the disease risk;
lifestyle and environmental factors are key contributors to the risk of MS. Importantly, these …

New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere
of excitement in the MS community. B cells are now known to play a major role in disease …

Multiple sclerosis is a chronic inflammatory disease of the CNS that results from the interplay
between heritable and environmental factors. Mounting evidence from different fields of …

Epstein–Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-
reactive antibodies might link EBV infection to CNS autoimmunity. As an altered anti-EBV T …

Although genetic susceptibility explains the clustering of multiple sclerosis (MS) within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …

Central nervous system B cells have several potential roles in multiple sclerosis (MS):
secretors of proinflammatory cytokines and chemokines, presenters of autoantigens to T …