The N-terminal domain of Three Prime Repair Exonuclease 1 (TREX1) is catalytically active
and can degrade dsDNA or ssDNA in the cytosol, whereas the C-terminal domain is …

Three-prime repair exonuclease 1 (TREX1) is a major 3′–5′ DNA exonuclease, which
digests cytosolic DNA to avoid inappropriate activation of the innate immune system …

Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to
the brain, retina, liver, and kidney. Based on the DNA damage theory of aging, we reasoned …

ABSTRACT HIV-1 DNA is preferentially integrated into chromosomal hot spots by the
preintegration complex (PIC). To understand the mechanism, we measured the DNA …

The time interval between HIV-1 infection and AIDS development is not the same in all
patients and depends largely on the genetic background of the individual. Polymorphisms in …

HIV-1 integration into the human genome is dependent on 3'-processing of the viral DNA.
Recently, we reported that the cellular Three Prime Repair Exonuclease 1 (TREX1) …

Cyclophilin A (CypA) promotes HIV-1 infection by facilitating reverse transcription, nuclear
entry and by countering the antiviral activity of TRIM5alpha. These multifunctional roles of …

ABSTRACT HIV-1 DNA is preferentially integrated into chromosomal hot spots by the
preintegration complex (PIC). To understand the mechanism, we measured the DNA …

DNA is compacted in the eukaryotic cell nucleus into chromatin by wrapping~ 147 bp of
DNA at a time around protein histone octamer cores composed of 2 each of histones H2A …

Human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired
immunodeficiency syndrome (AIDS), has infected over~ 79.3 million people worldwide with …