Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives
J Dumont, D Euwart, B Mei, S Estes… - Critical reviews in …, 2016 - Taylor & Francis
Biotherapeutic proteins represent a mainstay of treatment for a multitude of conditions, for
example, autoimmune disorders, hematologic disorders, hormonal dysregulation, cancers …
example, autoimmune disorders, hematologic disorders, hormonal dysregulation, cancers …
Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing
R O'Flaherty, A Bergin, E Flampouri, LM Mota… - Biotechnology …, 2020 - Elsevier
The manufacturing of recombinant protein is traditionally undertaken in mammalian cell
culture. Today, speed, cost and safety are the primary considerations for process …
culture. Today, speed, cost and safety are the primary considerations for process …
[HTML][HTML] Therapeutic glycoprotein production in mammalian cells
ME Lalonde, Y Durocher - Journal of biotechnology, 2017 - Elsevier
Over the last years, the biopharmaceutical industry has significantly turned its biologics
production towards mammalian cell expression systems. The presence of glycosylation …
production towards mammalian cell expression systems. The presence of glycosylation …
The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity
NA Pereira, KF Chan, PC Lin, Z Song - MAbs, 2018 - Taylor & Francis
Therapeutic monoclonal antibodies are the fastest growing class of biological therapeutics
for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy …
for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy …
Sialic acid O-acetylation patterns and glycosidic linkage type determination by ion mobility-mass spectrometry
GM Vos, KC Hooijschuur, Z Li, J Fjeldsted… - Nature …, 2023 - nature.com
O-acetylation is a common modification of sialic acids that has been implicated in a
multitude of biological and disease processes. A lack of analytical methods that can …
multitude of biological and disease processes. A lack of analytical methods that can …
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted
massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular …
massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular …
The art of CHO cell engineering: A comprehensive retrospect and future perspectives
Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system
for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of …
for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of …
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family
Glycosylation of proteins is an essential process in all eukaryotes and a great diversity in
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …
CHO cells in biotechnology for production of recombinant proteins: current state and further potential
Recombinant Chinese hamster ovary cells (rCHO) cells have been the most commonly used
mammalian host for large-scale commercial production of therapeutic proteins. Recent …
mammalian host for large-scale commercial production of therapeutic proteins. Recent …
[HTML][HTML] Genome sequence of foxtail millet (Setaria italica) provides insights into grass evolution and biofuel potential
Foxtail millet (Setaria italica), a member of the Poaceae grass family, is an important food
and fodder crop in arid regions and has potential for use as a C 4 biofuel. It is a model …
and fodder crop in arid regions and has potential for use as a C 4 biofuel. It is a model …