Novel and emerging treatments for major depression

S Marwaha, E Palmer, T Suppes, E Cons, AH Young… - The Lancet, 2023 - thelancet.com
Depression is common, costly, debilitating, and associated with increased risk of suicide. It is
one of the leading global public health problems. Although existing available …

Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: an international expert opinion on the available evidence and …

RS McIntyre, JD Rosenblat… - American Journal of …, 2021 - Am Psychiatric Assoc
Replicated international studies have underscored the human and societal costs associated
with major depressive disorder. Despite the proven efficacy of monoamine-based …

[HTML][HTML] Esketamine nasal spray versus quetiapine for treatment-resistant depression

A Reif, I Bitter, J Buyze, K Cebulla, R Frey… - … England Journal of …, 2023 - Mass Medical Soc
Background In treatment-resistant depression, commonly defined as a lack of response to
two or more consecutive treatments during the current depressive episode, the percentage …

The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders

GS Malhi, E Bell, D Bassett, P Boyce… - Australian & New …, 2021 - journals.sagepub.com
Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

New and emerging approaches to treat psychiatric disorders

KW Scangos, MW State, AH Miller, JT Baker… - Nature medicine, 2023 - nature.com
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Efficacy and safety of ketamine vs electroconvulsive therapy among patients with major depressive episode: a systematic review and meta-analysis

TG Rhee, SR Shim, BP Forester, AA Nierenberg… - JAMA …, 2022 - jamanetwork.com
Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among
patients with major depressive episode remains unknown. Objective To systematically …

Functional neuroimaging in psychiatry and the case for failing better

MM Nour, Y Liu, RJ Dolan - Neuron, 2022 - cell.com
Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders

MS García-Gutiérrez, F Navarrete, A Gasparyan… - Biomolecules, 2020 - mdpi.com
The potential therapeutic use of some Cannabis sativa plant compounds has been attracting
great interest, especially for managing neuropsychiatric disorders due to the relative lack of …

Maintenance ketamine treatment for depression: a systematic review of efficacy, safety, and tolerability

SY Smith-Apeldoorn, JKE Veraart, J Spijker… - The Lancet …, 2022 - thelancet.com
Ketamine has rapid yet often transient antidepressant effects in patients with treatment-
resistant depression. Different strategies have been proposed to prolong these effects …

Mechanisms of ketamine and its metabolites as antidepressants

EM Hess, LM Riggs, M Michaelides… - Biochemical pharmacology, 2022 - Elsevier
Treating major depression is a medical need that remains unmet by monoaminergic
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …