Ketone bodies in neurological diseases: focus on neuroprotection and underlying mechanisms

H Yang, W Shan, F Zhu, J Wu, Q Wang - Frontiers in neurology, 2019 - frontiersin.org
There is growing evidence that ketone bodies, which are derived from fatty acid oxidation
and usually produced in fasting state or on high-fat diets have broad neuroprotective effects …

Investigating the link between ketogenic diet, NAFLD, mitochondria, and oxidative stress: a narrative review

A Paoli, G Cerullo - Antioxidants, 2023 - mdpi.com
Together with the global rise in obesity and metabolic syndrome, the prevalence of
individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically …

Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

A Shao, S Tu, J Lu, J Zhang - Stem cell research & therapy, 2019 - Springer
The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not
effective. Stem cells are a type of cells that have the potential to differentiate into various …

Mitochondrial function in spinal cord injury and regeneration

PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Ketone metabolism in the failing heart

GD Lopaschuk, QG Karwi, KL Ho, S Pherwani… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The high energy demands of the heart are met primarily by the mitochondrial oxidation of
fatty acids and glucose. However, in heart failure there is a decrease in cardiac …

Stem cells therapy for spinal cord injury: an overview of clinical trials

S Silvestro, P Bramanti, O Trubiani… - International Journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a traumatic lesion that causes disability with temporary or
permanent sensory and/or motor deficits. The pharmacological approach still in use for the …

Common and divergent molecular mechanisms of fasting and ketogenic diets

A Paoli, GM Tinsley, MP Mattson, I De Vivo… - Trends in Endocrinology …, 2024 - cell.com
Intermittent short-term fasting (ISTF) and ketogenic diets (KDs) exert overlapping but not
identical effects on cell metabolism, function, and resilience. Whereas health benefits of KD …

Dietary prospects of coconut oil for the prevention and treatment of Alzheimer's disease (AD): A review of recent evidences

SV Ramesh, V Krishnan, S Praveen… - Trends in Food Science & …, 2021 - Elsevier
Background Alzheimer's disease (AD) is a devastating neurodegenerative ailment having
pathological hallmarks of plaques due to amyloid β (Aβ) peptides and neurofibrillary tangles …

Ketogenic diet attenuates oxidative stress and inflammation after spinal cord injury by activating Nrf2 and suppressing the NF-κB signaling pathways

Y Lu, YY Yang, MW Zhou, N Liu, HY Xing, XX Liu… - Neuroscience letters, 2018 - Elsevier
Oxidative stress and inflammation are two key secondary pathological mechanisms
following spinal cord injury (SCI). Ketogenic diet (KD) and its metabolite β-hydroxybutyrate …

Cuprizone-induced demyelination in mouse hippocampus is alleviated by ketogenic diet

C Liu, N Zhang, R Zhang, L Jin… - Journal of Agricultural …, 2020 - ACS Publications
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). Recently, ketogenic diet (KD) supplementation has attracted great …